个人简介
徐建国，“南湖学者”特聘教授，工学博士，博士后，硕士生导师，2017年6月博士毕业于福州大学化学学院，2017.6-2023.8人才引进在合肥工业大学食品与生物工程学院从事教学、科研工作，历任讲师（2017.6）、副教授（2019.12）。2023年9月高层次人才引进到嘉兴学院工作。主要从事功能核酸增敏感知体系构建，致力于疾病标志物分析、食品安全危害因子及环境危害物检测等方面的基础及应用研究。作为项目负责人主持包括国家自然科学基金、安徽省重点研发计划等科研项目10余项。已在本学科权威期刊（Anal. Chem., Biomaterials., Chem. Commun., Biosens. Bioelectron., J. Hazard, Mater., J. Agric. Food Chem.等）发表第一作者和通讯作者SCI收录论文50余篇(https://orcid.org/0000-0002-0187-2623)，其中包括中科院一区Top论文近40篇，自然指数刊物11篇，获第十四届福建省自然科学优秀学术论文三等奖。另专利转让1项，参编中英文专著2部，兼任国内第一本分析测试领域的英文期刊《Journal of Analysis and Testing》青年编委、《分析试验室》青年编委和中国药学会智能药学专委会委员，参与制定标准3项，获批主持国家青年基金、省重点研发计划、省重点研发计划子课题、省基金、中国博士后基金等多项省部级项目。
Email: jgxu0816@163.com;
主讲课程：仪器分析、生物安全与疫苗卫士
研究方向：
(1) 功能核酸探针设计与分子增敏感知平台构建
(2) 疾病标志物/食品安全危害因子/环境危害物分析检测
(3) 病原体检验检疫/抗菌技术构建、食品真实性鉴定
主持科研项目:
(1) 安徽省自然科学基金面上项目，2308085MB57，2023.9-2026.8项目主持人，在研；
(2) 安徽省重点研发计划项目，202104a07020008，2021.1-2023.12，项目子课题主持人，在研；
(3) 安徽省重点研发计划项目，2022e07020060，2022.1-2024.12，项目子课题主持人，在研；
(4) 国家自然科学基金青年基金项目，21804028，2019.01-2021.12，项目主持人，结题；
(5) 安徽省重点研发计划项目，202004h07020029，2020.01-2022.12，项目主持人，结题；
(6) 安徽省自然科学基金青年项目，1908085QC121，2019.07-2021.06，项目主持人，结题；
(7) 中国博士后基金面上项目，2019M652167，2019.06-2021.01，项目主持人，结题；
代表性论文（时间倒序）：
(1) Qi Wang, Baoqiang Chen, Dan Zheng, Juan Xia, Lijun Wu*, and Jianguo Xu*. Intramolecular Accelerated Assembly of Molecular Beacons: A DNA Nanoarchitecture-based Spatial Confinement Strategy toward Terminal Deoxynucleotidyl Transferase Biosensing. Anal. Chem., 2023, 95, 13708−13715. (自然指数)
(2) Xinlei Zhang, Yubo Peng, Li Yao, Huijie Shang, Zhi Zheng, Wei Chen*, and Jianguo Xu*. Self-assembly of a multivalent aptamer-tethered DNA monolayers dedicated to a fluorescence polarization-responsive circular isothermal strand displacement amplification for Salmonella assay. Anal. Chem., 2023, 95, 2570−2578 (自然指数)
(3) Huo Xu, Yanhui Zheng, Danlong Chen, Yinghao Cheng, Xiaojun Fang, Chunlian Zhong, Xinmei Huang, Qi Huang, Jiawei Xu, Jianguo Xu*, and Chang Xue*. A Branch-Shaped Trapping Device Regulates Accelerated Catalyzed Hairpin Assembly and Its Application for MicroRNA in Situ Imaging. Anal. Chem., 2023, 95, 1210−1218. (自然指数)
(4) Xiaoming Ma, Hui Zhang, Jin Liu, Huifang Zhang, Xuan Hu, Yu Wang, Xun Li, Jianguo Xu*. An ultrahigh-resolution multicolor sensing platform via target-induced etching of gold nanorods for multi-colorimetric analysis of trace silver ions. Sensors Actuat. B-Chem., 2023, 397, 134658.
(5) Yubo Peng, Huijie Shang, Zhi Zheng, Hongxia Li, Wei Chen*, and Jianguo Xu*. Self-activation of symbiotic multi-DNA machines transducing exponentially amplified fluorescence for ultrasensitively signaling of terminal deoxynucleotidyl transferase activity. Sensors Actuat. B-Chem., 2023, 380, 133400
(6) Huijie Shang, Yubo Peng, Li Yao, Zhi Zheng, Hongxia Li, Wei Chen*, Jianguo Xu*. Self-customized multi-channel exponential amplifications regulate powered monitoring of terminal deoxynucleotidyl transferase activity. Anal. Chem., 2022, 94, 32, 11401–11408 (自然指数)
(7) Jianguo Xu*, Xinlei Zhang, Chao Yan, Panzhu Qin, Li Yao, Qi Wang, Wei Chen*. Trigging isothermal circular amplification-based tuning of rigorous fluorescence quenching into complete restoration on a multivalent aptamer probe enables ultrasensitive detection of Salmonella. Anal. Chem., 2022, 94, 2, 1357–1364 (自然指数)
(8) Jie Wang Jie, Jiayin Sun, Jing Zhang, Chenlin Shen*, Xinlei Zhang, Jianguo Xu*. Engineered G-quadruplex-embedded self-quenching probes regulate single probe-based multiplex isothermal amplification to light road lamp probes for sensitized determination of microRNAs. Anal. Chem., 2022, 94, 10, 4437–4445 (自然指数)
(9) Juan Xia, Zhaoqiang Liu, Shulin Gao, Wenyong Li, Qi Wang*, Jianguo Xu*, Hai Wu*. Intermolecular and intramolecular priming co-directed synergistic multi-strand displacement amplification empowers ultrasensitive determination of microRNAs. Anal. Chem., 2022, 94, 16132−16141 (自然指数)
(10) Xinlei Zhang, Jianguo Xu*, Yubo Peng, Xinxin Wang, Huijie Shang, Li Yao, and Wei Chen* Dual-palindrome chained reaction regulates the formation of palindromic DNAzyme wire transducers empowering sensitized and one-step copper ion- dependent assay. Sensors Actuat. B-Chem., 2022, 370, 132471 ()
(11) Yinhuan Wu, Zhen Zeng, Ting Zhang, Chengxin Liu, Jianguo Xu*, Ruijie Deng, Qi Wang, and Feng Lin*. Synergetic dual-toehold mediated controllable transcription amplification for detecting lung cancer-related circulating miRNAs in blood. Sensors Actuat. B-Chem., 2022, 354, 131244 ()
(12) Qi Wang #, Wenyong Li #, Juan Xia, Hai Wu, Lijun Wu*, Jianguo Xu*. Stepwise tuning of a molecular beacon coupled Y probe regulates ternary DNA nanomachine-based microRNA determination. Sensors Actuat. B-Chem., 2022, 363, 131858
(13) Xinlei Zhang, Jianguo Xu*, Xiuguang Xing, Li Yao, Huijie Shang, Wei Chen*. Framework nucleic acid-wrapped protein-inorganic hybrid nanoflowers with three-stage amplified fluorescence polarization for terminal deoxynucleotidyl transferase activity biosensing. Biosens. Bioelectron., 2021, 193: 113564
(14) Xiaoming Ma, Zhen Wang, Xuan Hu, Jinghua Chen, Huifang Zhang, Xun Li, Fengyan Xie, Jianguo Xu*. Nanozyme catalysis-powered portable mini-drainage device enables realtime and universal weighing analysis of silver ions and silver nanoparticles. J. Hazard, Mater., 2021, 415, 125689.
(15) Xiuguang Xing, Li Yao, Chao Yan, Zhenlin Xu, Jianguo Xu*, Guodong Liu*, Bangben Yao*, and Wei Chen*. Recent progress of personal glucose meters integrated methods in food safety hazards detection. Crit. Rev. Food Sci., 2022, 62(27): 7413-7426.
(16) Jianguo Xu*, Zhi Li, Yumei Li, Yusheng Lu, and Jie Wang*. Activation of palindromes on a degradable modular grafting probe enables ultrasensitive detection of microRNAs. Chem. Commun., 2021, 57, 5941-5944 (自然指数)
(17) Xinlei Zhang, Jianguo Xu*, Chao Yan, Li Yao, Huijie Shang, Wei Chen*. Short- and long-range FRET co-functionalized fluorescence quenching collapsar probe regulates amplified and accelerated detection of Salmonella. J. Agric. Food Chem., 2021, 69, 14294−14301
(18) Xiaoming Ma, Shan He, Huifang Zhang, Xun Li*, Jun Xue, Xiaolin Fan, Yusheng Lu, Yiting Chen, Yanjie Zhang, and Jianguo Xu*. Delayed full opening of bumped switchable molecular probe enables repeated generation of target analogues for mix-to-signaling determination of microRNAs. Sensors Actuat. B-Chem., 2021, 327: 128875-128881
(19) Jie Wang, Shuhui Li, Jianguo Xu*, Yusheng Lu, Min Lin, Chaihung Wang, Chen Zhang, Guoxing Lin, Lee Jia*. Functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of microRNAs. Chem. Commun., 2020, 56, 1681-1684 (自然指数)
(20) Wei Chen, Jun Teng, Li Yao, Jianguo Xu*, and Guodong Liu. Selection of specific DNA aptamers for hetero-sandwich based colorimetric determination of Campylobacter jejuni in food. J. Agric. Food Chem., 2020, 68, 31, 8455–8461
(21) Wei Chen*, Lijun Yang, Chao Yan, Bangben Yao, Jian-feng Lu, Jianguo Xu*, and Guodong Liu*. Surface-confined building of Au@Pt-centered and multi-G-quadruplex/hemin wires-surrounded electroactive supernanostructures for ultrasensitive monitoring of morphine. ACS Sensors. 2020, 5, 8, 2644–2651
(22) Hongbo Li*, Mingbin Liu, Weihua Zhao, Jiamei Pu, Jianguo Xu*, Suqin Wang, Ruqin Yu*. Multi-channel collection of G-quadruplex transducers for amplified signaling of Pax-5 based on target-triggered split-to-intact remodeling of dual-G-rich duplex probe. Sensors Actuat. B-Chem., 2020, 311: 127913-127929
(23) Xiaoming Ma, Shan He, Ying Zhang, Jianguo Xu*, Huifang Zhang, Zhen Wang, Jun Xue, Xun Li,* Wenbo Yu*. Xiaolin Fan. Signal-off tuned signal-on (SF-T-SN) colorimetric immunoassay for amantadine using activity-metalmodulated peroxidase-mimicking nanozyme. Sensors Actuat. B-Chem., 2020, 311, 127933-127938
(24) Wei Chen*, Fen Cai, Qian Wu, Yuhan Wu, Bangben Yao, and Jianguo Xu*. Prediction, evaluation, confirmation, and elimination of mat. rix effects for lateral flow test strip based rapid and on-site detection of aflatoxin B1 in tea. Food Chem., 2020, 328, 127081
(25) Jianguo Xu#, Chao Yan#, Xinxin Wang, Bangben Yao, Jianfeng Lu, Guodong Liu*, Wei Chen*. Ingenious design of DNA concatamers and G-quadruplex wires assisted assembly of multi-branched DNA nanoarchitectures for ultrasensitive biosensing of miRNA. Anal. Chem., 2019, 91: 9747-9753(自然指数)
(26) Panzhu Qin, Li Yao, Jianguo Xu*, Guodong Liu, Wei Chen*. Smart engineering of a dual-DNA machine with a high signal-to-noise ratio for one-pot robust and sensitive miRNA signaling. Chem. Commun., 2019,55, 14367-14370 (自然指数)
(27) Wei Chen, Chao Yan, Lin Cheng, Li Yao, Feng Xue, Jianguo Xu*. An ultrasensitive signal-on electrochemical aptasensor for ochratoxin A determination based on DNA controlled layer-by-layer assembly of dual gold nanoparticle conjugates, Biosens. Bioelectron., 2018,117: 845–851
(28) Jianguo Xu, Zai-Sheng Wu*, Zhenmeng Wang, Jingqing Le, Tingting Zheng, Lee Jia*. Autonomous assembly of ordered metastable DNA nanoarchitecture and in situ visualizing of intracellular microRNAs, Biomaterials, 2017, 120: 57-65‘
(29) Jianguo Xu, Zai-Sheng Wu*, Weiyu Shen, Jingqing Le, Tingting Zheng, Hongling Li, Lee Jia*. Programmable nanoassembly consisting of two hairpin-DNAs for p53 gene determination, Biosens. Bioelectron., 2017, 94: 626-631
(30) Jianguo Xu, Zai-Sheng Wu*, Zhenmeng Wang, Hongling Li, Jingqing Le, and Lee Jia*, Two-wheel drive-based DNA nanomachine and its sensing potential for highly sensitive analysis of cancer-related gene, Biomaterials, 2016, 100: 110-117
(31) Jianguo Xu, Zai-Sheng Wu*, Hongling Li, Zhenmeng Wang, Jingqing Le, Tingting Zheng, Lee Jia*. Dual-cyclical nucleic acid strand-displacement polymerization based signal amplification system for highly sensitive determination of p53 Gene, Biosens. Bioelectron., 2016, 86: 1024-1030
(32) Jianguo Xu#, Jun Qian#, Hongling Li, Zai-Sheng Wu*, Weiyu Shen, Lee Jia*, Intelligent DNA machine for the ultrasensitive colorimetric detection of nucleic acids, Biosens. Bioelectron., 2016, 75: 41-47
(33) Jianguo Xu, Hongling Li, Zai-Sheng Wu*, Jun Qian, Chang Xue, Lee Jia*. Double-stem hairpin probe and ultrasensitive colorimetric detection of cancer-related nucleic acids, Theranostics, 2016, 6: 318-327
(34) Jianguo Xu, Haiyan Dong, Weiyu Shen, Sudan He, Hongling Li, Yusheng Lu, Zai-Sheng Wu*, Lee Jia*. New molecular beacon for p53 gene point mutation and significant potential in serving as the polymerization primer, Biosens. Bioelectron., 2015, 66: 504-511
(35) Jianguo Xu, Zai-Sheng Wu*, Weiyu Shen, Huo Xu, Hongling Li, Lee Jia*. Cascade DNA nanomachine and exponential amplification biosensing, Biosens. Bioelectron., 2015, 73: 19-25
专著及专利：
(1) 《食品安全学》，郑州大学出版社，编委，2019年12月
(2) Jianguo Xu, Li Yao, Lin Cheng, Chao Yan, and Wei Chen*. “Development of Aptamer-Based Electrochemical Methods.” Aptamers for Analytical Applications: Affinity Acquisition and Method Design, Willey publishing, 2018: 247-271.
(3) 徐建国; 陈伟; 闫超; 秦盼柱; 姚丽；一种检测microRNA-21的电化学传感器、其制备方法及应用； 2018-12-13, 中国专利, CN201811523457.5 （授权并转让）
(4) 徐建国; 陈伟; 秦盼柱; 闫超; 张超; 王昕昕; 高岩；2019-04-11, 中国专利,一种双重DNA机器检测microRNA-21的方法，CN201910288202.3（授权）
(5) 徐建国; 陈伟; 张鑫磊；2022-10-25，中国专利，一种功能性核酸探针及其制备方法与应用，CN202211312408.3
